WOMAN Trial
Does the early administration of tranexamic acid (TXA), compared with placebo, reduce death from bleeding in women with post-partum haemorrhage (PPH)?
Continue reading »Tag: Featured
Fragility Index
Fragility Index is the minimum number of patients whose status would have to change from a “non-event” (not having the primary endpoint) to an “event” (having the primary end point) in order to turn a statistically significant result to a nonsignificant result. It is a simple metric to calculate and use.
Reporting the Fragility Index in RCTs may help readers make more informed decisions about the confidence warranted by RCT results
Continue reading »DESIRE
In ventilated patients with sepsis, does a sedation strategy with dexmedetomidine compared with no dexmedetomidine improve mortality and number of ventilator-free days?
Continue reading »CHEETAH
In patients undergoing cardiac surgery with left ventricular dysfunction, does levosimendan compared to placebo reduce mortality?
Continue reading »MACMAN
In intensive care patients requiring orotracheal intubation, does video laryngoscopy (VL) compared to the Macintosh direct laryngoscope (DL) increase the frequency of first pass intubation?
Continue reading »LEVO-CTS
In patients with LVEF <35% undergoing cardiac surgery does levosimenden compared with placebo reduce the incidence of a composite outcome of: death at day 30; renal replacement therapy at day 30; perioperative myocardial infarct at day 5; and use of mechanical assist device at day 5
Continue reading »NIVAS
In patients who develop acute hypoxaemic respiratory failure after abdominal surgery, does non-invasive ventilation compared to standard oxygen therapy prevent the need for re-intubation?
Continue reading »Choudhury
In patients with cirrhosis and septic shock does terlipressin in comparison with noradrenaline improve haemodynamic parameters?
Continue reading »AMACING
In high-risk patients receiving contrast medium, does prophylactic hydration with normal saline compared to no prophylaxis impact the rate of contrast-induced nephropathy?
Continue reading »OPERA
In patients who have undergone major abdominal surgery does the application of high flow nasal cannulae compared with standard oxygen therapy, decrease the incidence of hypoxemia at one hour after extubation?
Continue reading »