Tag: Head Injury

IPC for prevention of upper limb venous thrombosis with PICCs

30 January 2026 Daniel Stubbins Intensive Care Medicine, Summaries Leave a comment

Intermittent pneumatic compression can reduce the incidence of upper extremity venous thrombosis after peripherally inserted central catheter placement in traumatic brain injury patients: A randomised control trial Liang et al. Australian Critical Care 2025; 38(6). doi:10.1016/j.aucc.2025.101308 Clinical Question In patients with traumatic brain injury (TBI) on neurointensive care with peripherally-inserted central catheters (PICC), does the use of upper-limb intermittent pneumatic […]

TRAIN – Transfusion Strategies in Acute Brain Injured Patients

26 October 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries One comment

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury @fabio_taccone. JAMA. 2024. PMID: 39382241 Clinical Question In patients with acute brain injury, does a liberal, compared to a restrictive strategy of blood transfusion, improve neurological outcomes at 180 days? Background The TRICC study, published over 20 years go, led to the widespread adoption of restrictive thresholds for blood […]

ANNEXA-I – Andexanet for Factor Xa Inhibitor–Associated ICH

10 July 2024 George Walker Emergency Medicine, Intensive Care Medicine One comment

In patients who have recently taken factor Xa inhibitors with an intracerebral haemorrhage (ICH) did the administration of Andexanet result in better haemostatic efficacy compared to standard care?

HEMOTION – transfusion thresholds in TBI

24 June 2024 Celia Bradford Intensive Care Medicine 2 comments

Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury Turgeon AF. NEJM June 13 2024; doi:10.1056/NEJMoa240360 Clinical Question In adult patients with moderate or severe traumatic brain injury, does a liberal transfusion strategy (transfusion if haemoglobin <10g/dl) compared to a restrictive strategy (transfusion if haemoglobin <7g/dl) reduce the rate of an unfavourable Glasgow Outcome Scale – Extended, at […]

PROPHY-VAP: Ceftriaxone to prevent early ventilator-associated pneumonia

8 February 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries Leave a comment

In patients with severe brain injury who require mechanical ventilation, does an early, single dose of ceftriaxone compared with placebo reduce the incidence of early VAP?

DECRA

8 April 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

In patients admitted to ICU with severe diffuse traumatic brain injury (TBI) and refractory raised intracranial pressure (ICP), does early decompressive craniectomy improve functional outcomes when compared with continued medical management?

Dex-CSDH

26 January 2021 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients with chronic subdural haemorrhage, what effect does dexamethasone compared with placebo have on neurological outcome at 6 months?

Propanalol in severe TBI

19 August 2020 Joel Swindin Intensive Care Medicine, Summaries 2 comments

Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomised Controlled trial Hosseinali Khalili. World J Surgery 2020; 44:1844-1853. https://doi.org/10.1007/s00268-020-05391-8 Clinical Question In patients with severe traumatic brain injury, does the administration of Beta-Blockade, compared with standard care alone, improve in-hospital mortality? Background The main aim of neurocritical in the management of traumatic brain injury is to mitigate the burden […]

CRASH-3

9 November 2019 George Walker Emergency Medicine, Summaries One comment

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH – 3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators. The Lancet, 2019; doi.org/10.1016/S1040-6736(19)32233-0 Clinical Question In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce […]

POLAR

26 October 2018 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?

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