Year: 2023

TGC-Fast: Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

11 June 2025 Daniel Chung Intensive Care Medicine Leave a comment

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU Gunst et al. N Engl J Med 2023;389:1180-1190 DOI: 10.1056/NEJMoa2304855 Clinical Question In ICU patients not receiving early parenteral nutrition, does liberal glucose control (initiating insulin when blood glucose level [BGL] >11.9 mmol per liter [>215 mg per deciliter]) or tight glucose control (commencing insulin at BGL 4.4 to 6.1 […]

MINT – Restrictive or Liberal Transfusion Strategy in Myocardial Infarction

23 May 2025 Daniel Chung Intensive Care Medicine Leave a comment

Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia Carson et al. NEJM 2023 DOI: 10.1056/NEJMoa2307983 Clinical Question In patients with myocardial infarction and anaemia, does a restrictive or liberal transfusion strategy decrease myocardial ischaemia or death at 30 days? Myocardial Ischemia and Transfusion (MINT) Trial Background Anaemia is common in patients with acute myocardial infarction and may exacerbate […]

Validation of the MIRACLE 2 Score for Prognostication After OOHCA

22 March 2024 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patient with out-of-hospital cardiac arrest, how does the MIRACLE2 score compare with previously reporting scoring systems, for predicting poor neurological outcome at hospital discharge?

EARLYDRAIN – Lumbar Cerebrospinal Fluid Drain Among Patients With aSAH

31 January 2024 Generic Contributor Intensive Care Medicine One comment

In patients with aneurysmal subarachnoid haemorrhage (aSAH), does lumbar CSF drainage compared to standard therapy improve clinical outcomes as measured by the modified Rankin Scale (mRS) score at 6 months?

ACORN

10 January 2024 George Walker Emergency Medicine, Intensive Care Medicine Leave a comment

In acutely ill adults (ED / ICU) does the administration of cefipime or piperacillin-tazobactam (pip-taz) result in an increased incidence of AKI or death by day 14?

Critical Care Evidence Updates – November 2023

10 January 2024 Rebecca Howes Blog, Evidence-based Medicine Leave a comment

What’s new in the Critical Care literature – monthly updates

Emergency Evidence Updates – November 2023

10 January 2024 Rebecca Howes Blog, Evidence-based Medicine One comment

What’s new in the Critical Care literature – monthly updates

STRESS-L: Landiolol and Organ Failure in Patients With Septic Shock

29 October 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

Landiolol and Organ Failure in Patients With Septic Shock Whitehouse. JAMA Published online October 25, 2023. doi:10.1001/jama.2023.20134 Clinical Question In patients with tachycardia and septic shock who are treated with high dose norepinephrine does the use of β-blockade for up to 14 days reduce organ failure compared to standard care? Background Many view the use of β-blockade as contentious in […]

Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage

24 October 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In trauma patients with exsanguinating haemorrhage, does the use of the REBOA (resuscitative endovascular balloon occlusion of the aorta) device with standard care in the emergency department, compared with standard care alone, impact 90-day-mortality?

Critical Care Evidence Updates – September 2023

19 October 2023 Rebecca Howes Blog, Evidence-based Medicine Leave a comment

What’s new in the Critical Care literature – monthly updates

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