Search Results for “Sepsis”

Immunosep – Precision Immunotherapy to Improve Sepsis Outcomes

21 January 2026 Patrick McNamara Intensive Care Medicine Leave a comment

Precision Immunotherapy to Improve Sepsis Outcomes Giamarellos-Bourboulis. JAMA 2025. doi:10.001/jama.2025.24175 Clinical Question In patients with sepsis, does immunotherapy (using either anakinra or human interferon gamma) that is tailored to the type of immune dysregulation lead to a reduction in organ dysfunction at day 9? Background Sepsis can involve a dysregulated immune response to an infection (SIDP, sepsis induced immune dysfunction) […]

ADAPT-Sepsis: PCT or CRP Guided Antibiotic Duration

24 January 2025 Hrishee Vaidya Intensive Care Medicine, Summaries Leave a comment

ADAPT-Sepsis: PCT or CRP-guided Antibiotic Duration for Patients with suspected Sepsis Dark et al. JAMA Dec 9 2024. doi:10.1001/jama.2024.26458 Clinical Question For critically ill adults with suspected sepsis, does a procalcitonin (PCT) guided or C-reactive protein (CRP) guided antibiotic discontinuation prompt, compared with usual care, reduce the total duration of antibiotics without increasing all-cause 28-day mortality? Background Shorter antibiotic durations […]

ASTER – Acetaminophen in Sepsis

9 January 2025 Generic Contributor Intensive Care Medicine Leave a comment

Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis Ware. JAMA 2024. doi:10.1001/jama.2024.8772 Clinical Question In critically ill adult patients with sepsis does the administration of acetaminophen compared to placebo increase the number of days alive and free of organ support to day 28? Background Acetaminophen is a potent and specific haemoprotein reductant that can […]

Vitamin C Sepsis

25 October 2019 Segun Olusanya Intensive Care Medicine, Summaries Leave a comment

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Fowler AA. JAMA; 2019;322(13):1261-1270 Clinical Question In patients with sepsis and acute respiratory distress syndrome, can intravenous administration of vitamin C, compared to placebo, reduce organ failure scores and biomarkers of inflammation and vascular injury? […]

Steroids in Sepsis

5 January 2018 Steve Mathieu Blog, Editorial 4 comments

In patients with septic shock, do corticosteroids compared to placebo reduce mortality?
This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.

SEPSISPAM

20 June 2014 David Slessor Intensive Care Medicine One comment

In patients with septic shock does a high target mean arterial pressure (MAP), compared to a low target MAP, improve mortality?

ACTiVE – Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation

28 March 2026 Tim Law Evidence-based Medicine, Intensive Care Medicine Leave a comment

Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Sinnige J. JAMA 2025. doi:10.1001/jama.2025.24384 Clinical Question Among critically ill mechanically ventilated adults, does early use of an automated closed-loop ventilation system (INTELLiVENT-ASV) increase ventilator-free days at day 28 (VFD-28) compared with protocolled conventional ventilation (CV)? Background Mechanical ventilation carries […]