Search Results for: Sepsis

RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults

Emergency Medicine, Intensive Care Medicine Leave a comment

Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Casey. NEJM. 2025. doi: 10.1056/NEJMoa2511420 Clinical Question Among adults with non‑traumatic critical illness undergoing emergency tracheal intubation in the ED or ICU, how does induction with ketamine (1–2 mg/kg IV, dosed by actual body weight) versus etomidate (0.2–0.3 mg/kg IV, dosed by actual body weight) affect 28‑day mortality? Background Peri-intubation […]

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ANDROMEDA-SHOCK2 – Personalized Hemodynamic Resuscitation

Evidence-based Medicine, Intensive Care Medicine Leave a comment

Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock ANDROMEDA SHOCK 2 Investigators @ShockAndromeda2. JAMA 2025. doi:10.1001/jama.2025.20402 Clinical Question In adult patients with early septic shock, does a personalised haemodynamic resuscitation protocol targeting capillary refill time (CRT) normalisation improve outcomes compared to usual care? Background In septic shock, the pathophysiological mechanisms contributing to the development of a shocked […]

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Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery

Peri-operative Medicine Leave a comment

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial  B Saugel. JAMA 2025; doi: 10.1001/jama.2025.17235 Clinical Question In patients undergoing major intra-abdominal surgery, does an individualised blood pressure target, compared to standard care, improve rates of acute kidney injury, acute myocardial infarction, non-fatal cardiac arrest or death within the first 7 days?  Background […]

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BICARICU-2: NaHCO3 for Metabolic Acidemia

Intensive Care Medicine Leave a comment

Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury Jung et al. JAMA 2025. doi: 10.1001/jama.2025.20231 Clinical Question In patients with severe metabolic acidosis (pH ≤7.20) and moderate to severe AKI  does the administration of sodium bicarbonate (NaHCO3) compared to placebo reduce 90-day mortality? Background Multiple cardiac, respiratory, renal and neurological pathophysiological consequences of severe academia have been reported […]

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