Emergency Evidence Updates – June 2024
What’s new in the Critical Care literature – monthly updates
Continue reading »Year: 2024
ENRICH: Early Minimally Invasive Removal of ICH
In patients with spontaneous intracranial haemorrhage (ICH), does the use of early minimally invasive surgery + standard management compared to standard management alone, result in better functional outcomes at 180 days?
Continue reading »REVISE – Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation
Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation (REVISE) D. Cook. NEJM 2024. DOI: 10.1056/NEJMoa2404245 Clinical Question In mechanically ventilated adults, does stress ulcer prophylaxis with intravenous pantoprazole (40 mg daily), compared with placebo (0.9% saline), reduce the occurrence of clinically important upper gastrointestinal bleeding at 90 days? Background Critical illness is associated with an increased risk of gastrointestinal (GI) stress […]
Continue reading »ANNEXA-I – Andexanet for Factor Xa Inhibitor–Associated ICH
In patients who have recently taken factor Xa inhibitors with an intracerebral haemorrhage (ICH) did the administration of Andexanet result in better haemostatic efficacy compared to standard care?
Continue reading »PROTECTION – Amino Acids for Kidney Protection
In adult patients scheduled for cardiac surgery with cardiopulmonary bypass does infusion of a balanced solution of amino acids, commencing at the time of surgery, compared with balanced crystalloid alone (Ringer’s Lactate) reduce the incidence of acute kidney injury (AKI)?
Continue reading »HEMOTION – transfusion thresholds in TBI
Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury Turgeon AF. NEJM June 13 2024; doi:10.1056/NEJMoa240360 Clinical Question In adult patients with moderate or severe traumatic brain injury, does a liberal transfusion strategy (transfusion if haemoglobin <10g/dl) compared to a restrictive strategy (transfusion if haemoglobin <7g/dl) reduce the rate of an unfavourable Glasgow Outcome Scale – Extended, at […]
Continue reading »DanGer Shock – Microaxial Flow Pump in Infarct-Related Cardiogenic Shock
Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock Møller JE et al. 2024. NEJM. DOI: 10.1056/NEJMoa2312572 Clinical Question In adults presenting with STEMI and cardiogenic shock does the use of a microaxial flow pump (Impella CP) compared to standard care reduce death from any cause at day 180? Background Cardiogenic shock is a frequent complication of STEMI and […]
Continue reading »NICO – Noninvasive Airway Management of Comatose Patients with Acute Poisoning
Effect of Noninvasive Airway Management of Comatose Patients with Acute Poisoning: A Randomized Clinical Trial Freund Y. JAMA. 2023. DOI: 10.1001/jama.2023.24391 Clinical Question In adults with a decreased conscious level from suspected acute poisoning, does withholding intubation versus routine practice reduce in-hospital death, and length of ICU stay and hospital stays? Background The decision to intubate a poisoned patient with […]
Continue reading »Validation of the MIRACLE 2 Score for Prognostication After OOHCA
In patient with out-of-hospital cardiac arrest, how does the MIRACLE2 score compare with previously reporting scoring systems, for predicting poor neurological outcome at hospital discharge?
Continue reading »Critical Care Evidence Updates – February 2024
What’s new in the Critical Care literature – monthly updates
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