TRISS
In patients with septic shock, does blood transfusion at a lower or higher haemoglobin threshold improve mortality?
Continue reading »Author: David Slessor
Doig
In critically ill patients with relative contraindications to early enteral nutrition (EN), does providing early parenteral nutrition (PN), improve mortality?
Continue reading »HOPE-ICU
In critically ill patients does early treatment with haloperidol decrease the time that survivors spend in delirium or coma?
Continue reading »PAC-MAN
Pulmonary Artery Catheters in patient Management PAC-MAN study group, Lancet 2005;366;472-477 Clinical Question In critically ill patients, does the use of a pulmonary artery catheter (PAC) reduce mortality? Design Randomised controlled trial Non-blinded Stratified by age and presumptive clinical syndrome Intention to treat analysis Power calculation: 1281 patients would allow detection of a 10% change in absolute hospital mortality, with […]
Continue reading »Annane
In patients with septic shock and relative adrenal deficiency does low dose corticosteroids improve 28 day mortality?
Continue reading »VSE
In patients in cardiac arrest, does vasopressin + epinephrine during CPR combined with steroid supplementation during and after CPR, improve survival to discharge with a good neurological outcome, in comparison to the use of epinephrine alone?
Continue reading »Bouderka
Does early tracheostomy reduce duration of mechanical ventilation and mortality in comparison with prolonged intubation in patients with head injury?
Continue reading »CATS
In patients with septic shock, is mortality affected by the use of adrenaline (epinephrine) alone in comparison to noradrenaline ± dobutamine?
Continue reading »Chatterjee
In patients with PE, does the addition of thrombolysis to anticoagulation, compared with anticoagulation alone, affect mortality and bleeding complications?
Continue reading »TOPCOAT
In patients with submassive PE, does the use of tenecteplase + heparin, compared to heparin alone, improve patient orientated outcomes?
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