SuDDICU
In mechanically ventilated adults, does the addition of selective decontamination of the digestive tract (SDD) compared to standard care reduce all-cause hospital mortality within 90 days?
Continue reading »Author: George Walker
Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis
In adults with acute pancreatitis does aggressive fluid resuscitation compared to moderate resuscitation result in a reduction in the development of moderately severe or severe pancreatitis?
Continue reading »CandiSep
In septic adults at high risk for invasive candida infection (ICI) does the use (1,3)-β-D-glucan (BDG) guided antifungal strategy, compared with standard treatment, reduce 28-day mortality compared to standard care?
Continue reading »Supplemental Parental Nutrition and Abdominal Surgery
In patients undergoing major abdominal surgery who are at high nutritional risk and have poor tolerance to enteral nutrition (EN) does the early use of supplemental parental nutrition (E-SPN), compared with late supplemental parental nutrition (L-SPN), reduce the risk of nosocomial infection?
Continue reading »Classic Trial
In adult patients in ICU with septic shock, does a restrictive approach to fluid therapy compared to a standard care result in fewer deaths at day 90?
Continue reading »SETPOINT2
In patients with severe stroke does early (≤5 days of intubation) tracheostomy when compared to standard timing (from day 10) of tracheostomy improve functional outcome at 6 months?
Continue reading »Endovascular Therapy for Large Ischemic Stroke
In patients with large cerebral infarction volumes does the use of endovascular therapy alongside medical care compared with medical care alone improve 90-day functional outcomes?
Continue reading »DECRA
In patients admitted to ICU with severe diffuse traumatic brain injury (TBI) and refractory raised intracranial pressure (ICP), does early decompressive craniectomy improve functional outcomes when compared with continued medical management?
Continue reading »Prague OHCA
In patients with a witnessed refractory out-of-hospital cardiac arrest (OHCA) does early intra-arrest transport, extracorporeal CPR (ECPR) and invasive assessment improve neurological outcome at 180 days?
Continue reading »PLUS Study
Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults Finfer S, NEJM, 2022; DOI: 10.1056/NEJMoa2114464 Clinical Question In critically ill adults does the use of a balanced multielectrolyte solution (BMES, Plasmalyte 148), as opposed to 0.9% Sodium Chloride, for fluid resuscitation and therapy result in reduced 90 day mortality? Background Fluid administration is a key component of critical care therapy […]
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