WOMAN Trial
Does the early administration of tranexamic acid (TXA), compared with placebo, reduce death from bleeding in women with post-partum haemorrhage (PPH)?
Continue reading »Author: Steve Mathieu
Steve is a Clinical Director and Consultant in Intensive Care and Anaesthesia at Queen Alexandra Hospital, Portsmouth, UK. He is co-editor of the The Bottom Line and ICM Case Summaries. He also has developed and maintains the Wessex ICS and Portsmouth ICU sites.
He is a Faculty Tutor for Intensive Care training and Council member of the Intensive Care Society. His interests include medical education, information technology and patient and relative experience.
@stevemathieu75
Fragility Index
Fragility Index is the minimum number of patients whose status would have to change from a “non-event” (not having the primary endpoint) to an “event” (having the primary end point) in order to turn a statistically significant result to a nonsignificant result. It is a simple metric to calculate and use.
Reporting the Fragility Index in RCTs may help readers make more informed decisions about the confidence warranted by RCT results
Continue reading »Critical Care Symposium 2017
Slides and handout from the the ‘Critical Care Game Changers’ (updates in critical care) presentation at Critical Care Symposium 2017
Continue reading »Marik
Does intravenous vitamin C, hydrocortisone and thiamine in addition to standard treatment, improve mortality in ICU patients with severe sepsis or septic shock, compared with standard treatment alone?
Continue reading »DasSMACC – count down to ticket release!
Finally we now know what DasSMACC has in store! Here are some inside tips that we have received from the SMACC organising committee that will help you prepare for the ticket release which is scheduled for Wednesday 8.00 am 26th October (Sydney Australian EST), or 22.00 London, 17.00 New York on the 25th of October for those on that side of the world. […]
Continue reading »LeoPARDS
In adult patients who have sepsis, does levosimendan reduce the incidence and severity of acute organ dysfunction compared with placebo?
Continue reading »RESCUEicp
In patients with a traumatic brain injury (TBI) and refractory intracranial hypertension, does decompressive craniectomy, result in more favourable mortality and neurological outcomes at 6 months, compared with barbiturate coma and continued medical management?
Continue reading »VANISH Trial
Does early vasopressin use reduce the risk of kidney failure in patients with septic shock compared with norepinephrine?
Continue reading »Kleine-Brueggeney
In patients having elective surgery and with a simulated difficult airway (using a cervical collar), does the choice of videolaryngoscope affect the first attempt intubation success rate?
Continue reading »The Refeeding Syndrome Trial
In critically ill patients with refeeding syndrome, does restricting caloric intake compared with unrestricted caloric feeding, reduce the composite outcome of ICU length of stay, overall survival time and mortality at day 60?
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