A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Emergency Medicine
In mechanically ventilated patients without acute respiratory distress syndrome (ARDS), does a low tidal volume ventilation strategy (6mL/Kg), compared to intermediate tidal volume strategy (10mL/Kg), reduce the number of ventilator-free and alive days at day 28?
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In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
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In adults suffering out-of-hospital non-traumatic cardiac arrest, does a strategy of airway management initially with laryngeal tube (LT) compared to endotracheal intubation (ETI) reduce mortality at 72 hours?
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In patients presenting to the Emergency Department with suspicion for acute coronary syndrome (ACS), does the use of a high-sensitivity troponin assay reduce subsequent myocardial infarction or cardiovascular death at 12 months when compared with the use of a standard troponin assay?
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In children with septic shock, does a restricted fluid bolus volume, compared with a standard fluid bolus volume, improve outcomes?
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In adult patients with non-traumatic out-of-hospital cardiac arrest, does a supraglottic airway device compared with tracheal intubation as the initial advanced airway management strategy, improve functional neurological outcome?
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In patients with acute myocardial infarction complicated by cardiogenic shock and evidence of multi-vessel disease on early diagnostic angiography, does immediate multi-vessel percutaneous coronary intervention (PCI) compared to culprit lesion only PCI (with staged revascularisation) improve outcome?
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In severely injured patients at risk for haemorrhagic shock, does prehospital plasma resuscitation, compared with standard-care resuscitation (not including plasma administration), reduce 30-day mortality?
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In adult patients with out-of-hospital cardiac arrest (OOHCA), does the administration of epinephrine compared to placebo improve survival?
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In infants (<12 months) with bronchiolitis and hypoxaemia (saturations <92%) in the emergency department or general paediatric ward, does early treatment with high flow therapy versus standard oxygen therapy result in fewer infants having treatment failure that leads to escalation of care?
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