DIABOLO
Does acetazolamide reduce the duration of mechanical ventilation in critically ill patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis?
Continue reading »A compendium of critical appraisals in Intensive Care Medicine research and related specialties
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Does acetazolamide reduce the duration of mechanical ventilation in critically ill patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis?
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In patients with traumatic intracerebral haemorrhage (TICH), does early surgery (haematoma evacuation within 12 h of randomisation) compared with initial conservative management reduce major disability and death at 6 months after injury?
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In healthy adults taking either apixaban (ANNEXA-A) or rivaroxaban (ANNEXA-R) does andexanet alfa compared to placebo normalise anticoagulation?
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Does early rehabilitation reduce physical impairment and ICU length of stay in critically ill patients?
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In adult ICU patients with severe sepsis does the use of continuous infusion (CI) of beta-lactam antibiotics compared to intermittent bolus (IB) improve clinical outcomes?
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In patients presenting with acute uncomplicated appendicitis, is antibiotic therapy non-inferior to appendicectomy surgery?
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In paediatric patients with septic shock, does adrenaline compared with dopamine reduce 28 day mortality?
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In critical care doctors, does mulled wine compared to normal saline, improve the sense of well-being and ICU length of stay?
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In patients with traumatic brain injury (TBI), does hypothermia (32-35°C) and standard care compared to standard care alone reduce death and major disability at 6 months after injury?
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In adult patients with suspected bacterial infections, does procalcitonin-guided antibiotic care compared to usual care reduce patient exposure to antibiotics without increasing mortality?
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