A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In patients with LVEF <35% undergoing cardiac surgery does levosimenden compared with placebo reduce the incidence of a composite outcome of: death at day 30; renal replacement therapy at day 30; perioperative myocardial infarct at day 5; and use of mechanical assist device at day 5
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In patients presenting to the Emergency Department with chest pain, does the HEART Pathway compared with usual care, reduce objective cardiac testing?
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In patients with septic shock who are mechanically ventilated does indexed LV end-diastolic area and respiratory changes in aortic blood velocity predict the haemodynamic effects of volume expansion?
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Are there specific ECG characteristics that can differentiate between anterior ST-elevation myocardial infarction (STEMI) and early repolarisation?
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In patients with wide QRS (probably ventricular) tachycardia, does intravenous procainamide compared with intravenous amiodarone reduce major adverse cardiac events?
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In patients aged 80 years or older, with unstable angina/non-ST elevation myocardial infaction (NSTEMI), does an early invasive strategy compared with a conservative strategy, reduce the composite outcome of myocardial infarction, need for urgent revascularisation, stroke and death?
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In adult patients with nontraumatic out-of-hospital cardiac arrest and shock-refractory ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT), does amiodarone or lidocaine along with standard care result in improved survival and more favourable neurological outcome compared with placebo?
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In patients with ST-elevation-myocardial infarction (STEMI), without hypoxia, does receiving supplemental oxygen compared with no supplemental oxygen reduce early myocardial injury?
Continue reading »Does a modified Valsalva technique, incorporating a leg lift procedure, result in improved success in converting a supraventricular tachycardia to sinus rhythm in patients presenting to the Emergency Department?
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In elective surgical patients with atrial fibrillation who are suspending their normal warfarin peri-operatively, does no bridging anticoagulation compared to bridging anticoagulation with dalteparin increase the incidence of thromboembolism or reduce the incidence of major bleeding?
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