RELIEF
In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?
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DAWN
In patients who are 6-24 hours post acute stroke, and have a mismatch between clinical deficit and infarct, does thrombectomy plus standard medical care, compared to standard medical care alone, improve functional outcomes at 90 days?
Continue reading »Stockl
In adult patients post out of hospital cardiac arrest does a continuous or on demand application of neuromuscular blockade (NMB) reduce the number of shivering episodes during targeted temperature management (TTM)?
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In peri-operative patients at low to moderate risk of post-operative complications, does goal-directed haemodynamic therapy using oesophageal doppler monitoring compared to standard care, reduce the incidence of post-operative complications within 180 days?
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In patients with status epilepticus (SE) and cluster attacks of seizures, (CS) does IV levetiracetam vs. IV phenytoin improve rate of control of seizures?
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In critically ill adults, does the administration of ramelteon compared to placebo reduce the length of intensive care stay?
Continue reading »Intensive Insulin Therapy
In post-operative patients requiring mechanical ventilation, does intensive insulin therapy compared to conventional insulin therapy reduce mortality?
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In patients with proximal internal carotid (ICA) or middle cerebral artery (MCA) occlusion with likely salvageable ischaemic brain tissue, does thrombectomy, at 6-16 hours post ischaemic stroke, in addition to medical therapy, compared to medical therapy alone, improve functional outcome at 90 days?
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In delirium free critically ill adult patients receiving sedation, does the addition of nocturnal low dose dexmedetomidine prevent delirium and improve sleep?
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In critically ill patients with septic shock, does the combination of hydrocortisone plus fludrocortisone therapy reduce 90 day mortality?
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