Tag: Oxygen

LOGICAL – Conservative Oxygen after Cardiac Arrest

Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. NEJM. 2026. doi: 10.1056/NEJMoa2513814 Clinical Question In patients who are unresponsive after cardiac arrest, does limiting oxygen exposure to achieve acceptable oxygenation increase the likelihood of surviving with a favourable functional outcome Background Brain damage and unfavourable […]

UK-ROX Trial

27 June 2025 Celia Bradford Intensive Care Medicine Leave a comment

Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients Martin. JAMA June 12 2025; doi:10.1001/jama.2025.9663 Clinical Question In mechanically ventilated adult patients in the ICU, does a strategy of conservative oxygen therapy, targeting a SpO2 of 90% (Range 88-92%) compared with usual care, reduce mortality at 90 days? Background In the United Kingdom, around 184,000 adults are admitted to […]

TRAUMOX2 – Early Restrictive vs Liberal Oxygen for Trauma Patients

15 December 2024 George Walker Emergency Medicine, Intensive Care Medicine Leave a comment

Early Restrictive vs Liberal Oxygen for Trauma Patients Arleth. JAMA 2024. doi: 10.1001/jama.2024.25786 Clinical Question In adult patients experiencing blunt or penetrating trauma does an early restrictive oxygen strategy compared to a liberal oxygen strategy reduce death and/or major respiratory complications within 30 days? Background ATLS guidelines recommend that all severely injured patients should receive supplemental oxygen in the initial […]

PILOT

2 December 2022 Omar Jundi Intensive Care Medicine 2 comments

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation Semler. N Engl J Med 2022; 387:1759-1769. DOI: 10.1056/NEJMoa2208415 Clinical Question In patients receiving invasive mechanical ventilation, does a target oxygen saturation of 90%, 94%, or 98% increase days alive and free of mechanical ventilation at 28 days? Background Despite the ubiquity of oxygen therapy in the critical care setting, the […]

BOX (Oxygen)

8 November 2022 David Slessor Intensive Care Medicine, Summaries Leave a comment

In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?

SHINE

29 April 2022 David Slessor Intensive Care Medicine, Summaries Leave a comment

In neonates undergoing elective endotracheal intubation, does nasal high-flow therapy compared with standard care, improve 1st pass success without physiological instability?

Sjöblom

29 April 2021 Fraser Magee Emergency Medicine, Intensive Care Medicine, Peri-operative Medicine Leave a comment

In adult patients undergoing rapid sequence intubation for emergency surgery, does pre-oxygenation with high-flow nasal oxygen, compared with standard face-mask oxygen, reduce the incidence of oxygen desaturation?

HOT-ICU

25 February 2021 Luke Collett Intensive Care Medicine Leave a comment

In patients with acute hypoxaemic respiratory failure, does a lower vs higher oxygenation target reduce mortality at 90 days?

ICU-ROX

1 November 2019 Celia Bradford Intensive Care Medicine 2 comments

In mechanically ventilated ICU patients does a conservative use of oxygen therapy compared to usual oxygen therapy affect the number of ventilator-free-days?

Zochios

30 August 2019 Peter Szedlak Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients at high risk of respiratory complications after cardiac surgery, does the routine application of high-flow nasal oxygen compared to standard oxygen reduce hospital length of stay?

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