A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In critically ill patients on noradrenaline for haemodynamic support, who required hemofiltration for AKI, does the use of a high cutoff hemofilter compared with a standard hemofilter impact the median hours of noradrenaline-free time at day 7?
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For surrogate decision makers of critically ill patients, does a multi-component family support intervention impact on the surrogates’ hospital anxiety and depression scale (HADS) at 6 months?
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In severely injured patients at risk for haemorrhagic shock, does prehospital plasma resuscitation, compared with standard-care resuscitation (not including plasma administration), reduce 30-day mortality?
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In adult patients with out-of-hospital cardiac arrest (OOHCA), does the administration of epinephrine compared to placebo improve survival?
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In critically ill patients with septic shock, does the use of terlipressin compared to norepinephrine reduced 28-day mortality?
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In infants (<12 months) with bronchiolitis and hypoxaemia (saturations <92%) in the emergency department or general paediatric ward, does early treatment with high flow therapy versus standard oxygen therapy result in fewer infants having treatment failure that leads to escalation of care?
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In selected non-trauma patients presenting to the emergency department with undifferentiated hypotension, does a standardised point-of-care ultrasound protocol, compared with usual care, improve 30 day or hospital survival?
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In critically ill patients with severe metabolic acidaemia (pH ≤7⋅20), does the infusion of sodium bicarbonate, compared with no infusion, to reach and maintain a targeted pH of 7⋅30 decrease the primary composite outcome of mortality by day 28 or the presence of at least one organ failure at day 7?
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In patients with sepsis, critical illness, stroke, trauma, myocardial infarction, cardiac arrest and those who had emergency surgery does a liberal oxygen strategy compared with a conservative oxygen strategy increase hospital mortality?
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In patients with anterior circulation strokes undergoing endovascular thrombectomy, is IV thrombolysis within 4.5 hours of stroke onset with tenecteplase, non-inferior to alteplase, at establishing reperfusion?
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