IDEAL-ICU
patients with septic shock and severe acute kidney injury, does early vs. delayed renal replacement therapy improve 90 day mortality?
Continue reading »Year: 2018
POLAR
In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
Continue reading »EUPHRATES
In adult patients with septic shock and high circulating endotoxin activity, does the use of polymyxin B haemoperfusion therapy significantly decrease 28-day mortality?
Continue reading »PART
In adults suffering out-of-hospital non-traumatic cardiac arrest, does a strategy of airway management initially with laryngeal tube (LT) compared to endotracheal intubation (ETI) reduce mortality at 72 hours?
Continue reading »TRICS-III 6 month follow up
In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis at 6 months after surgery?
Continue reading »High STEACS
In patients presenting to the Emergency Department with suspicion for acute coronary syndrome (ACS), does the use of a high-sensitivity troponin assay reduce subsequent myocardial infarction or cardiovascular death at 12 months when compared with the use of a standard troponin assay?
Continue reading »Vollam
In patients discharged from a general ICU, is discharge “out-of-hours” compared to discharge “in-hours” associated with subsequent in-hospital mortality?
Continue reading »FiSh
In children with septic shock, does a restricted fluid bolus volume, compared with a standard fluid bolus volume, improve outcomes?
Continue reading »AIRWAYS-2
In adult patients with non-traumatic out-of-hospital cardiac arrest, does a supraglottic airway device compared with tracheal intubation as the initial advanced airway management strategy, improve functional neurological outcome?
Continue reading »CULPRIT-SHOCK: One year follow up
In patients with acute myocardial infarction complicated by cardiogenic shock and evidence of multi-vessel disease on early diagnostic angiography, does immediate multi-vessel percutaneous coronary intervention (PCI) compared to culprit lesion only PCI (with staged revascularisation) improve outcome?
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