Year: 2024

TRAIN – Transfusion Strategies in Acute Brain Injured Patients

Intensive Care Medicine, Summaries Leave a comment

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury @fabio_taccone. JAMA. 2024. PMID: 39382241 Clinical Question In patients with acute brain injury, does a liberal, compared to a restrictive strategy of blood transfusion, improve neurological outcomes at 180 days? Background The TRICC study, published over 20 years go, led to the widespread adoption of restrictive thresholds for blood […]

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REVISE – Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation

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Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation (REVISE) D. Cook. NEJM 2024. DOI: 10.1056/NEJMoa2404245 Clinical Question In mechanically ventilated adults, does stress ulcer prophylaxis with intravenous pantoprazole (40 mg daily), compared with placebo (0.9% saline), reduce the occurrence of clinically important upper gastrointestinal bleeding at 90 days? Background Critical illness is associated with an increased risk of gastrointestinal (GI) stress […]

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HEMOTION – transfusion thresholds in TBI

Intensive Care Medicine 2 comments

Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury Turgeon AF. NEJM June 13 2024; doi:10.1056/NEJMoa240360 Clinical Question In adult patients with moderate or severe traumatic brain injury, does a liberal transfusion strategy (transfusion if haemoglobin <10g/dl) compared to a restrictive strategy (transfusion if haemoglobin <7g/dl) reduce the rate of an unfavourable Glasgow Outcome Scale – Extended, at […]

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