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In adult ICU patients with severe sepsis does the use of continuous infusion (CI) of beta-lactam antibiotics compared to intermittent bolus (IB) improve clinical outcomes?
Continue reading »A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In adult ICU patients with severe sepsis does the use of continuous infusion (CI) of beta-lactam antibiotics compared to intermittent bolus (IB) improve clinical outcomes?
Continue reading »In intensive care patients who require a central venous catheter (CVC), does the choice of insertion site affect the complication rates?
Continue reading »In critically ill patients, does the use of a balanced crystalloid solution compared to normal saline effect the incidence of acute kidney injury?
Continue reading »In patients with severe community-acquired pneumonia and high inflammatory response, does the use of corticosteroids compared to placebo improve outcom
Continue reading »In adult patients with septic shock, does early goal-directed therapy (EGDT) compared with standard therapy reduce mortality at 90 days?
Continue reading »In brain-dead organ donors does the use of protocolised fluid therapy compared to usual care improve the number of organs transplanted?
Continue reading »In trauma patients with or at risk of significant haemorrhage, does the early administration of a short course of tranexamic acid (TXA) affect the mortality, incidence of occlusive events and the amount of blood transfused?
Continue reading »In patients with severe trauma and predicted to require massive transfusion, does the use of a transfusion protocol using a 1:1:1 ratio of plasma to platelets to red blood cells (RBCs) compared to 1:1:2 improve mortality?
Continue reading »In patients with septic shock, does Activated Protein C (also known as drotrecogin alfa or DrotAA) compared with placebo reduce mortality?
Continue reading »Does the use of Selective Decontamination of the Digestive Tract (SDD) affect ICU and hospital mortality and the acquisition of resistant organisms?
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