RECOVERY: COVID-19 dexamethasone
In hospitalised patients with SARS-CoV-2 infection does dexamethasone in additional to usual care, compared to usual care alone, reduce 28-day mortality?
Continue reading »Author: Celia Bradford
Boulware
In people who have high-risk or moderate-risk exposure to someone with confirmed COVID-19 infection, does taking hydroxychloroquine following the exposure compared to placebo reduce the incidence of a new illness compatible with COVID-19?
Continue reading »FABLED
In patients with severe sepsis what is the sensitivity of blood cultures taken after the initiation of antimicrobial therapy?
Continue reading »65 Trial
In patients older than 65-years with vasodilatory hypotension receiving vasopressors, does a target mean arterial pressure (MAP) of 60-65mmHg compared with usual care impact mortality?
Continue reading »ICU-ROX
In mechanically ventilated ICU patients does a conservative use of oxygen therapy compared to usual oxygen therapy affect the number of ventilator-free-days?
Continue reading »PAUSE
In patients with atrial fibrillation (AF) on direct oral anticoagulant (DOAC) medications, does a standard approach to therapy interruption and resumption in the perioperative period result in an acceptable risk for bleeding and thromboembolic events?
Continue reading »SPICE III
In ventilated, critically ill patients, does the use of dexmedetomidine as the primary sedative agent compared with usual sedative agents effect 90 day mortality?
Continue reading »CENSER
In patients with septic shock, does early low-dose norepinephrine compared with standard care increase shock control at six hours?
Continue reading »TARGET
In mechanically ventilated, critically ill patients receiving enteral nutrition does energy-dense feed (1.5kCal/ml) compared with routine feed (1kCal/ml) impact on 90 day all cause mortality?
Continue reading »POLAR
In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
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