Celia Bradford

PALACS

Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery Mario Gaudino, The Lancet Dec 4 2021; 398: 2075–83 https://doi.org/10.1016/S0140-6736(21)02490-9 Clinical Question In selected patients undergoing cardiac surgery, does posterior left pericardiotomy compared with usual care, reduce the incidence of postoperative atrial fibrillation? Background Atrial fibrillation is common following cardiac surgery with approximately one-third of patients developing […]

COV-BARRIER

9 September 2021 Celia Bradford Intensive Care Medicine Leave a comment

In hospitalised adult patient with COVID-19, does baricitinib compared with placebo decrease a composite outcome of progression of illness and mortality?

RECOVERY-RS

22 August 2021 Celia Bradford Intensive Care Medicine 5 comments

In hospitalised patients with COVID-19 requiring >40% FiO2 to achieve SaO2>94%, does the use of continuous positive airway pressure (CPAP) or high flow nasal oxygen (HFNO) compared with conventional O2 therapy (COT) reduce the incidence of tracheal intubation or death within 30 days?

TTM2

17 June 2021 Celia Bradford Intensive Care Medicine 2 comments

In patients who are unconscious following out-of-hospital cardiac arrest, does targeted hypothermia compared with targeted normothermia, impact all-cause mortality?

REALITY

6 March 2021 Celia Bradford Intensive Care Medicine Leave a comment

In patients with acute myocardial infarction and anaemia is a restrictive, compared with a liberal transfusion strategy, non-inferior with respect to major adverse cardiovascular outcomes at 30 days?

Dex-CSDH

26 January 2021 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients with chronic subdural haemorrhage, what effect does dexamethasone compared with placebo have on neurological outcome at 6 months?

BACC

24 December 2020 Celia Bradford Intensive Care Medicine Leave a comment

In hospitalised patients with severe acute respiratory syndrome due to coronavirus 2 (SAR-CoV-2), does tocilizumab compared with placebo, reduce intubation rates or mortality?

RECOVERY: COVID-19 Kaletra

21 October 2020 Celia Bradford Intensive Care Medicine Leave a comment

In patients admitted to hospital with COVID-19, does Lopinavir-ritonavir therapy (Kaletra) compared to usual care, reduce 28-day mortality?

STARRT-AKI

17 July 2020 Celia Bradford Intensive Care Medicine 5 comments

Standard versus Accelerated Initiation of Renal Replacement Therapy Wald R, Bagshaw S. NEJM July 16 2020 doi:10.1056/NEJMoa2000741 Clinical Question In critically ill patients with severe acute kidney injury, does accelerated initiation of renal replacement therapy compared to standard initiation improve 90 day survival? Background Acute Kidney Injury (AKI) is common in critically ill patients and some case series suggest up […]

RECOVERY: COVID-19 dexamethasone

3 July 2020 Celia Bradford Intensive Care Medicine Leave a comment

In hospitalised patients with SARS-CoV-2 infection does dexamethasone in additional to usual care, compared to usual care alone, reduce 28-day mortality?

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