RECOVERY: COVID-19 Kaletra
In patients admitted to hospital with COVID-19, does Lopinavir-ritonavir therapy (Kaletra) compared to usual care, reduce 28-day mortality?
Continue reading »Category: Intensive Care Medicine
A collection of TBL summaries relevant to Intensive Care Medicine
ITACTIC
In adult trauma patients presenting with signs of haemorrhagic shock does the utilisation of a viscoelastic haemostatic assay (VHA) augmented transfusion strategy compared to a strategy augmented by conventional coagulation tests (CCT) result in an increased number of patients alive and free of massive transfusion at 24 hours?
Continue reading »REDECAP
In conscious critically ill patients who have had a tracheostomy inserted as part of their ICU stay and have been weaned from mechanical ventilation, does an assessment of readiness for decannulation that is based on suctioning frequency, when compared to an assessment based on tracheostomy capping, result in a shorter time to successful decannulation?
Continue reading »MIDAS
In patients aged > 18 years who were unable to be liberated from vasopressors for 24 hours, did the addition of midodrine when compared to a placebo result in the earlier discontinuation of vasopressors?
Continue reading »ATESS
In patients with septic shock, does the use of intravenous vitamin C and thiamine compared to standard therapy improve recovery from organ failure?
Continue reading »REMAP-CAP
In patients with severe COVID-19, does intravenous hydrocortisone (either as a fixed dose or restricted to when shock is clinically evident) compared with standard care, improve 21-day organ support free days?
Continue reading »LOCO2
In patients with acute respiratory distress syndrome (ARDS), does conservative vs. liberal oxygen reduce death at 28 days?
Continue reading »Propanalol in severe TBI
Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomised Controlled trial Hosseinali Khalili. World J Surgery 2020; 44:1844-1853. https://doi.org/10.1007/s00268-020-05391-8 Clinical Question In patients with severe traumatic brain injury, does the administration of Beta-Blockade, compared with standard care alone, improve in-hospital mortality? Background The main aim of neurocritical in the management of traumatic brain injury is to mitigate the burden […]
Continue reading »GRECCO-19
In patients hospitalised with symptomatic coronavirus disease 2019, does the administration of colchicine improve clinical & laboratory outcomes?
Continue reading »STARRT-AKI
Standard versus Accelerated Initiation of Renal Replacement Therapy Wald R, Bagshaw S. NEJM July 16 2020 doi:10.1056/NEJMoa2000741 Clinical Question In critically ill patients with severe acute kidney injury, does accelerated initiation of renal replacement therapy compared to standard initiation improve 90 day survival? Background Acute Kidney Injury (AKI) is common in critically ill patients and some case series suggest up […]
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