A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Intensive Care Medicine
In haematology or ICU patients with platelet counts between 10,000 and 50,000 per mm3, is receiving no prophylactic platelets non inferior compared to the administration of 1u platelets in order to reduce the risk of catheter-related bleeding?
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In critically ill adults undergoing tracheal intubation, does the use of a videolaryngoscope (VL) compared to a direct laryngoscope (DL) improve the first-pass success rate?
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In patients resuscitated from out-of-hospital cardiac arrest (OOHCA) does targeted mild hypercapnia compared to targeted normocapnia improve 6-month neurological outcomes?
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In adult patients with major trauma, who are at risk for trauma-induced coagulopathy does early administration of 1g of tranexamic acid (TXA) followed by an infusion of 1g over 8 hours, compared with placebo, increase survival with a favourable functional outcome at 6 months?
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In patients in the ICU with delirium, does haloperidol compared with placebo, increase the number of days alive and out of the hospital at 90 days?
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In patients with severe community acquired pneumonia (CAP) does the use of hydrocortisone compared to a placebo reduce 28-day mortality?
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In patients with refractory out-of-hospital cardiac arrest (OHCA) and an initial ventricular arrhythmia, does extracorporeal cardiopulmonary resuscitation (ECPR), as compared with conventional CPR (CCPR), improve survival with a favourable neurologic outcome
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In critically ill patients, does a higher dose of protein compared to usual dose protein, improve time-to-discharge-alive from hospital up to 60 days?
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In patients with severe cardiogenic shock does immediate initiation of VA-ECMO, compared to a trial of conservative therapy and the possibility of rescue VA ECMO, reduce a composite outcome of death, resuscitated cardiac arrest or commencement of another mechanical circulatory support?
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In patients with sepsis-induced hypotension does a restrictive fluid strategy (with early vasopressor usage) compared to a liberal fluid strategy result in lower mortality before discharge by day 90?
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