Gujjar
In patients with status epilepticus (SE) and cluster attacks of seizures, (CS) does IV levetiracetam vs. IV phenytoin improve rate of control of seizures?
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Nishikimi
In critically ill adults, does the administration of ramelteon compared to placebo reduce the length of intensive care stay?
Continue reading »Intensive Insulin Therapy
In post-operative patients requiring mechanical ventilation, does intensive insulin therapy compared to conventional insulin therapy reduce mortality?
Continue reading »DEFUSE 3
In patients with proximal internal carotid (ICA) or middle cerebral artery (MCA) occlusion with likely salvageable ischaemic brain tissue, does thrombectomy, at 6-16 hours post ischaemic stroke, in addition to medical therapy, compared to medical therapy alone, improve functional outcome at 90 days?
Continue reading »Skrobik
In delirium free critically ill adult patients receiving sedation, does the addition of nocturnal low dose dexmedetomidine prevent delirium and improve sleep?
Continue reading »APROCCHSS
In critically ill patients with septic shock, does the combination of hydrocortisone plus fludrocortisone therapy reduce 90 day mortality?
Continue reading »EPaNIC
In critically ill adult patients, does late supplemental parenteral nutrition (PN), compared with early PN reduce the duration of dependency on intensive care?
Continue reading »SALT-ED
In non-critically ill adult patients admitted to hospital from the Emergency Department, does the administration of a balanced salt solution compared with normal saline, reduce hospital free days to day 28?
Continue reading »SMART
In critically ill patients does the administration of balanced crystalloids compared with saline, reduce a 30 day composite outcome of death, new renal replacement therapy or persistent renal dysfunction?
Continue reading »READS
For healthcare professionals interpreting chest radiographs, does an educational intervention compared to no educational intervention improve the diagnosis or exclusion of acute respiratory distress syndrome (ARDS)
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