Classic Trial
In adult patients in ICU with septic shock, does a restrictive approach to fluid therapy compared to a standard care result in fewer deaths at day 90?
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HYPO-ECMO
In patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenation(VA-ECMO), does early use of moderate hypothermia (33-34°C) compared with strict normothermia (36-37 °C) improve 30 day mortality?
Continue reading »FAKT
In patients requiring rapid sequence intubation (RSI) in the emergency department does the addition of fentanyl to ketamine and rocuronium reduce the frequency of patients having a systolic blood pressure (SBP) outside of a target range of 100-150mmHg?
Continue reading »SETPOINT2
In patients with severe stroke does early (≤5 days of intubation) tracheostomy when compared to standard timing (from day 10) of tracheostomy improve functional outcome at 6 months?
Continue reading »Endovascular Therapy for Large Ischemic Stroke
In patients with large cerebral infarction volumes does the use of endovascular therapy alongside medical care compared with medical care alone improve 90-day functional outcomes?
Continue reading »SHINE
In neonates undergoing elective endotracheal intubation, does nasal high-flow therapy compared with standard care, improve 1st pass success without physiological instability?
Continue reading »DECRA
In patients admitted to ICU with severe diffuse traumatic brain injury (TBI) and refractory raised intracranial pressure (ICP), does early decompressive craniectomy improve functional outcomes when compared with continued medical management?
Continue reading »RePHILL
In patients with trauma-related haemorrhagic shock does prehospital administration of packed red cells and lyophilised plasma (Lyo-Plas) compared with normal saline reduce the composite outcome of mortality and failure to reach lactate clearance?
Continue reading »Prague OHCA
In patients with a witnessed refractory out-of-hospital cardiac arrest (OHCA) does early intra-arrest transport, extracorporeal CPR (ECPR) and invasive assessment improve neurological outcome at 180 days?
Continue reading »TELSTAR
In comatose survivors of cardiac arrest does the treatment of rhythmic and periodic electroencephalographic (EEG) patterns improve neurological outcome compared with standard care?
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