Tag: Neurology

IPC for prevention of upper limb venous thrombosis with PICCs

30 January 2026 Daniel Stubbins Intensive Care Medicine, Summaries Leave a comment

Intermittent pneumatic compression can reduce the incidence of upper extremity venous thrombosis after peripherally inserted central catheter placement in traumatic brain injury patients: A randomised control trial Liang et al. Australian Critical Care 2025; 38(6). doi:10.1016/j.aucc.2025.101308 Clinical Question In patients with traumatic brain injury (TBI) on neurointensive care with peripherally-inserted central catheters (PICC), does the use of upper-limb intermittent pneumatic […]

SAHARA – Liberal vs Restrictive Transfusion Targets in SAH

18 December 2024 Celia Bradford Intensive Care Medicine Leave a comment

Liberal versus Restrictive Transfusion in Aneurysmal Subarachnoid Haemorrhage English S. NEJM 2024 DOI:10.1056/NEJMoa2410962 Clinical Question In patients following acute aneurysmal subarachnoid haemorrhage, does a liberal strategy of blood transfusion compared with a restrictive strategy of blood transfusion reduce unfavourable neurological outcome? SubArachnoid Haemorrhage Red-cell transfusion And Outcome (SAHaRA) Background Anaemia is common following aneurysmal subarachnoid haemorrhage with an incidence of approximately 50% during the […]

Pupillometry Thresholds for Neuroprognostication

22 November 2024 stephen.waite2@nhs.scot Intensive Care Medicine, Summaries Leave a comment

Validating quantitative pupillometry thresholds for neuroprognostication after out‑of‑hospital cardiac arrest. A predefined substudy of the Blood Pressure and Oxygenations Targets After Cardiac Arrest (BOX)‑trial Nyholm. Intensive Care Med 2024; 50:1484–1495. doi.org/10.1007/s00134-024-07574-6 Clinical Question In adult out-of-hospital cardiac arrest (OHCA) survivors of presumed cardiac cause who are comatose post-admission, do automated pupillometry thresholds of quantitatively assessed pupillary light reflex (qPLR) < […]

TRAIN – Transfusion Strategies in Acute Brain Injured Patients

26 October 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries One comment

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury @fabio_taccone. JAMA. 2024. PMID: 39382241 Clinical Question In patients with acute brain injury, does a liberal, compared to a restrictive strategy of blood transfusion, improve neurological outcomes at 180 days? Background The TRICC study, published over 20 years go, led to the widespread adoption of restrictive thresholds for blood […]

ENRICH: Early Minimally Invasive Removal of ICH

15 July 2024 Generic Contributor Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients with spontaneous intracranial haemorrhage (ICH), does the use of early minimally invasive surgery + standard management compared to standard management alone, result in better functional outcomes at 180 days?

Validation of the MIRACLE 2 Score for Prognostication After OOHCA

22 March 2024 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patient with out-of-hospital cardiac arrest, how does the MIRACLE2 score compare with previously reporting scoring systems, for predicting poor neurological outcome at hospital discharge?

PROPHY-VAP: Ceftriaxone to prevent early ventilator-associated pneumonia

8 February 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries Leave a comment

In patients with severe brain injury who require mechanical ventilation, does an early, single dose of ceftriaxone compared with placebo reduce the incidence of early VAP?

EARLYDRAIN – Lumbar Cerebrospinal Fluid Drain Among Patients With aSAH

31 January 2024 Generic Contributor Intensive Care Medicine One comment

In patients with aneurysmal subarachnoid haemorrhage (aSAH), does lumbar CSF drainage compared to standard therapy improve clinical outcomes as measured by the modified Rankin Scale (mRS) score at 6 months?

SETPOINT2

20 May 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

In patients with severe stroke does early (≤5 days of intubation) tracheostomy when compared to standard timing (from day 10) of tracheostomy improve functional outcome at 6 months?

Endovascular Therapy for Large Ischemic Stroke

13 May 2022 George Walker Emergency Medicine, Intensive Care Medicine, Summaries 2 comments

In patients with large cerebral infarction volumes does the use of endovascular therapy alongside medical care compared with medical care alone improve 90-day functional outcomes?

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