POLAR
In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
Continue reading »Tag: Neurology
EXTEND IA TNK
In patients with anterior circulation strokes undergoing endovascular thrombectomy, is IV thrombolysis within 4.5 hours of stroke onset with tenecteplase, non-inferior to alteplase, at establishing reperfusion?
Continue reading »DAWN
In patients who are 6-24 hours post acute stroke, and have a mismatch between clinical deficit and infarct, does thrombectomy plus standard medical care, compared to standard medical care alone, improve functional outcomes at 90 days?
Continue reading »Gujjar
In patients with status epilepticus (SE) and cluster attacks of seizures, (CS) does IV levetiracetam vs. IV phenytoin improve rate of control of seizures?
Continue reading »DEFUSE 3
In patients with proximal internal carotid (ICA) or middle cerebral artery (MCA) occlusion with likely salvageable ischaemic brain tissue, does thrombectomy, at 6-16 hours post ischaemic stroke, in addition to medical therapy, compared to medical therapy alone, improve functional outcome at 90 days?
Continue reading »PRECISE
In patients with moderate-to-severe sciatica, does pregabalin compared to placebo reduce leg pain?
Continue reading »HYBERNATUS
In patients with convulsive status epilepticus, does the addition of therapeutic hypothermia to standard care improve neurological outcomes?
Continue reading »POCUS: Moretti
In mechanically ventilated patients with subarachnoid hemorrhage (SAH), does the distensibility of IVC on ultrasound, predict fluid responsiveness measured by thermodilution?
Continue reading »PATCH
In patients with acute intracerebral haemorrhage, associated with antiplatelet therapy, does platelet transfusion compared with standard care reduce death or dependence?
Continue reading »RESCUEicp
In patients with a traumatic brain injury (TBI) and refractory intracranial hypertension, does decompressive craniectomy, result in more favourable mortality and neurological outcomes at 6 months, compared with barbiturate coma and continued medical management?
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