Tag: Shock

ANDROMEDA-SHOCK2 – Personalized Hemodynamic Resuscitation

Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock ANDROMEDA SHOCK 2 Investigators @ShockAndromeda2. JAMA 2025. doi:10.1001/jama.2025.20402 Clinical Question In adult patients with early septic shock, does a personalised haemodynamic resuscitation protocol targeting capillary refill time (CRT) normalisation improve outcomes compared to usual care? Background In septic shock, the pathophysiological mechanisms contributing to the development of a shocked […]

DanGer Shock – Microaxial Flow Pump in Infarct-Related Cardiogenic Shock

26 April 2024 George Walker Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock Møller JE et al. 2024. NEJM. DOI: 10.1056/NEJMoa2312572 Clinical Question In adults presenting with STEMI and cardiogenic shock does the use of a microaxial flow pump (Impella CP) compared to standard care reduce death from any cause at day 180? Background Cardiogenic shock is a frequent complication of STEMI and […]

PATCH

19 June 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In adult patients with major trauma, who are at risk for trauma-induced coagulopathy does early administration of 1g of tranexamic acid (TXA) followed by an infusion of 1g over 8 hours, compared with placebo, increase survival with a favourable functional outcome at 6 months?

DOREMI

2 September 2021 Luke Collett Intensive Care Medicine Leave a comment

Milrinone as compared with Dobutamine in the Treatment of Cardiogenic Shock Matthew. N Engl J Med 2021; 385:516-525, doi: 10.1056/NEJMoa2026845 Clinical Question In patients with cardiogenic shock, does milrinone as compared with dobutamine improve the composite outcome of in-hospital death, resuscitated cardiac arrest, receipt of cardiac transplant or mechanical circulatory support, non-fatal myocardial infarction, cerebrovascular event or renal replacement therapy? […]

ATESS

16 September 2020 Adrian Wong Intensive Care Medicine Leave a comment

In patients with septic shock, does the use of intravenous vitamin C and thiamine compared to standard therapy improve recovery from organ failure?

FABLED

13 March 2020 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In patients with severe sepsis what is the sensitivity of blood cultures taken after the initiation of antimicrobial therapy?

VITAMINS

19 January 2020 Steve Mathieu Emergency Medicine, Intensive Care Medicine 2 comments

Does treatment with vitamin C, hydrocortisone, and thiamine lead to a more rapid resolution of septic shock compared with hydrocortisone alone?

Atan

24 August 2018 Celia Bradford Intensive Care Medicine Leave a comment

In critically ill patients on noradrenaline for haemodynamic support, who required hemofiltration for AKI, does the use of a high cutoff hemofilter compared with a standard hemofilter impact the median hours of noradrenaline-free time at day 7?

PAMPer

3 August 2018 Aidan Burrell Emergency Medicine One comment

In severely injured patients at risk for haemorrhagic shock, does prehospital plasma resuscitation, compared with standard-care resuscitation (not including plasma administration), reduce 30-day mortality?

Liu

20 July 2018 Adrian Wong Intensive Care Medicine One comment

In critically ill patients with septic shock, does the use of terlipressin compared to norepinephrine reduced 28-day mortality?

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