Kumar
In patients with septic shock, what is the relationship between appropriateness of initial empiric antimicrobial therapy and survival?
Continue reading »Year: 2000-2009
These are summaries of trials published in the decade 2000 to 2009.
ABC Trial
In mechanically ventilated and sedated patients, do Spontaneous Awakening Trials (SAT) in addition to Spontaneous Breathing Trials (SBT) reduce dependence on mechanical ventilation?
Continue reading »Ramachandran
In obese patients with simulated difficult laryngoscopy, does the use of nasal oxygen prolong the duration that oxygen saturations remain ≥95%?
Continue reading »KETASED
In critically ill adults, does a single induction dose of etomidate compared to ketamine affect organ failure scores during the subsequent first 3 days?
Continue reading »ARF Trial Network
In critically ill patients with acute kidney injury (AKI) does intensive compared with ‘less intensive’ renal-replacement therapy (RRT) improve mortality?
Continue reading »Rivers
In adults with severe sepsis or septic shock, does the use of early goal-directed therapy (EGDT) reduce the mortality?
Continue reading »Bellomo
In patients renal dysfunction, does dopamine reduce the severity of acute kidney injury?
Continue reading »De Jonge
Does the use of Selective Decontamination of the Digestive Tract (SDD) affect ICU and hospital mortality and the acquisition of resistant organisms?
Continue reading »PAC-MAN
Pulmonary Artery Catheters in patient Management PAC-MAN study group, Lancet 2005;366;472-477 Clinical Question In critically ill patients, does the use of a pulmonary artery catheter (PAC) reduce mortality? Design Randomised controlled trial Non-blinded Stratified by age and presumptive clinical syndrome Intention to treat analysis Power calculation: 1281 patients would allow detection of a 10% change in absolute hospital mortality, with […]
Continue reading »CRASH-1
In adults with a head injury, do early corticosteroids compared to placebo reduce death and disability?
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