Kacmarek
In patients with ARDS does open-lung ventilation compared with ARDSnet ventilation improve 60 day mortality?
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MULLET
In critical care doctors, does mulled wine compared to normal saline, improve the sense of well-being and ICU length of stay?
Continue reading »Eurotherm3235
In patients with traumatic brain injury (TBI), does hypothermia (32-35°C) and standard care compared to standard care alone reduce death and major disability at 6 months after injury?
Continue reading »BLING2
In adult ICU patients on beta-lactam antibiotics, does continuous infusion compared to intermittent bolus increase survival?
Continue reading »THAPCA-OH
In children suffering an out-of-hospital cardiac arrest, does hypothermia compared to normothermia increase survival with a good neurobehavioural outcome?
Continue reading »VITdAL-ICU
In critically ill patients with low serum vitamin D levels, does high-dose vitamin D supplementation compared with placebo reduce hospital length of stay?
Continue reading »CHEER
In patients who are in refractory cardiac arrest, does protocolised management involving mechanical CPR, Hypothermia, ECMO and early reperfusion improve survival rate?
Continue reading »ABC Trial
In mechanically ventilated and sedated patients, do Spontaneous Awakening Trials (SAT) in addition to Spontaneous Breathing Trials (SBT) reduce dependence on mechanical ventilation?
Continue reading »TracMan
In mechanically ventilated adult patients with a high risk of prolonged ventilation, does early tracheostomy compared with late tracheostomy reduce mortality at 30 days?
Continue reading »SEPSISPAM
In patients with septic shock does a high target mean arterial pressure (MAP), compared to a low target MAP, improve mortality?
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