Search Results for: PILOT

SAHARA – Liberal vs Restrictive Transfusion Targets in SAH

Intensive Care Medicine Leave a comment

Liberal versus Restrictive Transfusion in Aneurysmal Subarachnoid Haemorrhage English S. NEJM 2024 DOI:10.1056/NEJMoa2410962 Clinical Question In patients following acute aneurysmal subarachnoid haemorrhage, does a liberal strategy of blood transfusion compared with a restrictive strategy of blood transfusion reduce unfavourable neurological outcome? SubArachnoid Haemorrhage Red-cell transfusion And Outcome (SAHaRA) Background Anaemia is common following aneurysmal subarachnoid haemorrhage with an incidence of approximately 50% during the […]

Continue reading »

TRAUMOX2 – Early Restrictive vs Liberal Oxygen for Trauma Patients

Emergency Medicine, Intensive Care Medicine Leave a comment

Early Restrictive vs Liberal Oxygen for Trauma Patients Arleth. JAMA 2024. doi: 10.1001/jama.2024.25786 Clinical Question In adult patients experiencing blunt or penetrating trauma does an early restrictive oxygen strategy compared to a liberal oxygen strategy reduce death and/or major respiratory complications within 30 days? Background ATLS guidelines recommend that all severely injured patients should receive supplemental oxygen in the initial […]

Continue reading »

Quetiapine Versus Haloperidol for Delirium

Intensive Care Medicine, Summaries Leave a comment

Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium: Randomized Controlled Trial Zakhary et al. Neurocritical Care; Oct;41(2):550-557. doi:10.1007/s12028-024-01948-w Clinical Question In critically ill patients with delirium, does quetiapine in comparison to haloperidol, reduce the severity of delirium? Background Delirium affects 30-50% of adult ICU patients Haloperidol is licensed for the treatment of acute delirium in the UK  Previous RCTs […]

Continue reading »
1 2 3 4 5 … 12