Year: 2021

PALACS

Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery Mario Gaudino, The Lancet Dec 4 2021; 398: 2075–83 https://doi.org/10.1016/S0140-6736(21)02490-9 Clinical Question In selected patients undergoing cardiac surgery, does posterior left pericardiotomy compared with usual care, reduce the incidence of postoperative atrial fibrillation? Background Atrial fibrillation is common following cardiac surgery with approximately one-third of patients developing […]

CONTROLING

Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial Bohé. Intensive Care Medicine 2021. https://doi.org/10.1007/s00134-021-06526-8 Clinical Question In critically unwell adults does targeting individualised glycaemic control compared to glycaemia < 180 mg/dL improve 90 day mortality? Background Hyperglycaemia has been shown to result in worse outcomes in the critically ill, especially in non-diabetic patients In […]

Critical Care Evidence Updates – November 2021

16 December 2021 Steve Mathieu Blog, Evidence-based Medicine Leave a comment

What’s new in the Critical Care literature – monthly updates

COMBAT-COVID

10 December 2021 David Slessor Intensive Care Medicine, Summaries Leave a comment

In mechanically ventilated patients with COVID-19 and severe endotheliopathy, does prostacylin compared with placebo, improve days alive without ventilation by day 28?

COCA

3 December 2021 David Slessor Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In patients with out-of-hospital cardiac arrest, does calcium compared with placebo, improve sustained return of spontaneous circulation?

Critical Care Evidence Updates – October 2021

18 November 2021 Steve Mathieu Blog, Evidence-based Medicine Leave a comment

What’s new in the Critical Care literature – monthly updates

SILENCE

17 November 2021 David Slessor Intensive Care Medicine, Summaries Leave a comment

In patients near end of life, does subcutaneous scopolamine butylbromide compared with placebo, reduce the incidence of death rattle?

SNOCAT

22 October 2021 Daniel Hu Emergency Medicine, Summaries Leave a comment

Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest: A Randomized Clinical Trial Kim @uwcardiology. JAMA. 2021 January 12;325(2):138-145. doi: 10.1001/jama.2020.24326. Clinical Question In patients with out-of-hospital cardiac arrest, does sodium nitrite, compared with placebo, improve survival to hospital admission? Background Out-of-hospital cardiac arrest continues to have a high risk of morbidity and mortality Nitrate therapy […]

VAM-IHCA

15 October 2021 George Walker Intensive Care Medicine One comment

Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial Anderson et al. JAMA 2021. doi:10.1001/jama.2021.16628 Clinical Question In adult patients suffering an in-hospital cardiac arrest (IHCA) does the use of vasopressin and methylprednisolone compared to a placebo result in increased rates of return of spontaneous circulation (ROSC)? […]

COAST

8 October 2021 Fraser Magee Emergency Medicine, Summaries Leave a comment

In hypoxic African children (oxygen saturations of between 80 and 91%) with pneumonia, does oxygen therapy reduce mortality when compared with a permissive hypoxia (no oxygen) strategy?
In severely hypoxic children (oxygen saturations less than 80%), does high-flow nasal therapy reduce mortality when compared with low-flow oxygen therapy?

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