Acetazolamide in Acute Decompensated Heart Failure with Volume Overload
In adult patients with acute decompensated heart failure (ADHF), does the addition of acetazolamide to loop diuretics improve decongestion by day 3?
Continue reading »Author: George Walker
Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia
In haematology or ICU patients with platelet counts between 10,000 and 50,000 per mm3, is receiving no prophylactic platelets non inferior compared to the administration of 1u platelets in order to reduce the risk of catheter-related bleeding?
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In critically ill adults undergoing tracheal intubation, does the use of a videolaryngoscope (VL) compared to a direct laryngoscope (DL) improve the first-pass success rate?
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In patients resuscitated from out-of-hospital cardiac arrest (OOHCA) does targeted mild hypercapnia compared to targeted normocapnia improve 6-month neurological outcomes?
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In patients with severe community acquired pneumonia (CAP) does the use of hydrocortisone compared to a placebo reduce 28-day mortality?
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In patients with sepsis-induced hypotension does a restrictive fluid strategy (with early vasopressor usage) compared to a liberal fluid strategy result in lower mortality before discharge by day 90?
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In adults with an expected ICU stay of > 72 hours, does the provision of enteral melatonin compared to placebo increase the number of delirium-free assessments within 14 days or before ICU discharge?
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Early Active Mobilization during Mechanical Ventilation in the ICU @chodgsonANZICRC @TEAMtrialICU. NEJM 2022; 387:1747-58 doi:10.1056/NEJMoa2209083 Clinical Question In mechanically ventilated adult patients does the provision of early mobilisation when compared to standard care increase the number of days alive and out of hospital at 180 days? Background ICU Acquired weakness (ICUAW) is common with one systematic review reporting a median […]
Continue reading »TBL Mini: Rib Fixation
Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomised Clinical Trial Dehghan et al. JAMA Surg 2022 doi:10.1001/jamasurg.2022.4299 Background Blunt chest wall trauma has high associated rates of morbidity and mortality RCTs have shown a reduced ICU length of stay in those requiring mechanical ventilation, however this has not been replicated in non-ventilated patients What did they […]
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In mechanically ventilated adults, does the addition of selective decontamination of the digestive tract (SDD) compared to standard care reduce all-cause hospital mortality within 90 days?
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