Tag: Featured

LEAP2

Is 5-day oral lefamulin non-inferior to 7-day oral moxifloxacin in the management of community-acquired bacterial pneumonia?

ANTHARTIC

Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest Francois et al. N Engl J Med 2019;381:1831-42. DOI: 10.1056/NEJMoa1812379 Clinical Question In post out-of-hospital cardiac arrest patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia? Background Rates of survival to hospital discharge and good neurological outcomes post out-of-hospital cardiac arrest (OOHCA) remain poor Despite […]

Sessler

29 November 2019 Segun Olusanya Peri-operative Medicine Leave a comment

In patients with breast cancer having potentially curative surgery, does a strategy of paravertebral block and propofol anaesthesia, compared to a strategy of opioid and sevoflurane anaesthesia, reduce local or metastatic recurrence?

COLCOT

22 November 2019 David Slessor Intensive Care Medicine Leave a comment

In patients post myocardial infarction, does low dose colchicine compared with placebo, reduce ischaemic cardiovascular events?

CRASH-3

9 November 2019 George Walker Emergency Medicine, Summaries One comment

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH – 3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators. The Lancet, 2019; doi.org/10.1016/S1040-6736(19)32233-0 Clinical Question In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce […]

ICU-ROX

1 November 2019 Celia Bradford Intensive Care Medicine 2 comments

In mechanically ventilated ICU patients does a conservative use of oxygen therapy compared to usual oxygen therapy affect the number of ventilator-free-days?

Vitamin C Sepsis

25 October 2019 Segun Olusanya Intensive Care Medicine, Summaries Leave a comment

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Fowler AA. JAMA; 2019;322(13):1261-1270 Clinical Question In patients with sepsis and acute respiratory distress syndrome, can intravenous administration of vitamin C, compared to placebo, reduce organ failure scores and biomarkers of inflammation and vascular injury? […]

Subira

20 October 2019 Duncan Chambler Intensive Care Medicine Leave a comment

In patients weaning from mechanical ventilation, does a spontaneous breathing trial (SBT) with pressure support (PS) for 30 minutes vs a SBT with T-piece for 2 hours differ in the rate of successful liberation from mechanical ventilation (MV)?