HIGH
In immunocompromised patients with acute hypoxic respiratory failure (AHRF), does the use of high flow oxygen as opposed to standard oxygen therapy, reduce 28 day mortality?
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PReVENT
In mechanically ventilated patients without acute respiratory distress syndrome (ARDS), does a low tidal volume ventilation strategy (6mL/Kg), compared to intermediate tidal volume strategy (10mL/Kg), reduce the number of ventilator-free and alive days at day 28?
Continue reading »MIND-USA
In delirious adult ICU patients, does the administration of haloperidol or ziprasidone reduce the duration of delirium when compared with placebo?
Continue reading »SUP-ICU
In ICU patients at risk of gastrointestinal (GI) bleeding does the use of prophylactic proton-pump inhibitor (PPI) compared to placebo reduce mortality at 90 days?
Continue reading »IDEAL-ICU
patients with septic shock and severe acute kidney injury, does early vs. delayed renal replacement therapy improve 90 day mortality?
Continue reading »POLAR
In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
Continue reading »EUPHRATES
In adult patients with septic shock and high circulating endotoxin activity, does the use of polymyxin B haemoperfusion therapy significantly decrease 28-day mortality?
Continue reading »IMPACT
In adult patients at risk of nausea and vomiting during surgery, do multiple antiemetic interventions compared to single antiemetic interventions or no intervention reduce nausea and vomiting?
Continue reading »PART
In adults suffering out-of-hospital non-traumatic cardiac arrest, does a strategy of airway management initially with laryngeal tube (LT) compared to endotracheal intubation (ETI) reduce mortality at 72 hours?
Continue reading »TRICS-III 6 month follow up
In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis at 6 months after surgery?
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