TTM2
In patients who are unconscious following out-of-hospital cardiac arrest, does targeted hypothermia compared with targeted normothermia, impact all-cause mortality?
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STYLETO
In critically ill adults, does the use of an intubating stylet compared to tracheal tube alone, increase first-attempt successful intubation?
Continue reading »TRAAP2
In patients undergoing caesarean section (CS) does the administration of tranexamic acid (TXA) when compared to placebo result in a lower incidence of calculated estimated blood loss of red blood cell transfusion by day 2?
Continue reading »MENDS2
In mechanically ventilated adults with sepsis, does the use of dexmedetomidine, compared with propofol, for continuous sedation improve the number of days alive without delirium or coma?
Continue reading »Sjöblom
In adult patients undergoing rapid sequence intubation for emergency surgery, does pre-oxygenation with high-flow nasal oxygen, compared with standard face-mask oxygen, reduce the incidence of oxygen desaturation?
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In adults presenting with subarachnoid haemorrhage (SAH), does ultra early short term treatment with tranexamic acid improve clinical outcome at 6 months?
Continue reading »DEXA-ARDS
In patients with moderate-severe ARDS, does dexamethasone in addition to routine care, compared with routine care alone increase ventilator free days up to day 28?
Continue reading »FEISTY
In adult trauma patients with major haemorrhage and hypofibrinogenaemia does the use fibrinogen concentrate (FC) compared to cryoprecipitate (cryo) result in a shorter time to administration?
Continue reading »CERTA
In critically ill patients with acute altered level of consciousness and no recent seizures, does continuous EEG (cEEG) compared to repeated routine EEG (rEEG) correlate with reduced mortality?
Continue reading »SHIPMAN
In adults presenting to the ED with a corneal abrasion is topical tetracaine more effective than placebo to control pain at a 24-48 hour follow up appointment?
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