TICH-2
In adults with acute, spontaneous intra-cerebral haemorrhage (ICH), does the administration of tranexamic acid (TXA) compared to a placebo improve functional status at 90 days?
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iPROVE
In adult patients undergoing abdominal surgery, with intermediate-to-high-risk of post-operative pulmonary complications, will an individualised perioperative open-lung ventilation strategy (iPROVE), compared with standard protective ventilation, result in fewer post-operative complications during the first 7 days post surgery
Continue reading »CENSER
In patients with septic shock, does early low-dose norepinephrine compared with standard care increase shock control at six hours?
Continue reading »Pivetta
In patients who presented to the Emergency Department (ED) with acute dyspnoea, does the addition of lung ultrasound examination compared to standard approach, improve the diagnostic accuracy for acute decompensated heart failure (ADHF)?
Continue reading »The IRIS Cricoid Trial
In patients undergoing rapid sequence anaesthesia induction, does the use of cricoid pressure vs. a sham procedure, prevent pulmonary aspiration?
Continue reading »HERCULES
In patients with acquired thrombocytopenia purport, does calpacizumab compared with placebo, reduce the time to normalisation of the platelet count?
Continue reading »RACE
Do one or more doses of levocarnitine reduce organ failure in septic shock at 48 hours, compared with placebo?
Continue reading »TARGET
In mechanically ventilated, critically ill patients receiving enteral nutrition does energy-dense feed (1.5kCal/ml) compared with routine feed (1kCal/ml) impact on 90 day all cause mortality?
Continue reading »Don’t forget the LEGO
In adult subjects who ingest a small toy part, compared to historical controls of children who have ingested coins, is there a difference in object transit time and complication rate?
Continue reading »BREATHE
In adult patients on invasive mechanical ventilation who are difficult to wean, does extubation and weaning on non-invasive ventilation compared to weaning on invasive ventilation reduce the time until liberation from mechanical ventilation?
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