A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In patients presenting to the Emergency Department with suspicion for acute coronary syndrome (ACS), does the use of a high-sensitivity troponin assay reduce subsequent myocardial infarction or cardiovascular death at 12 months when compared with the use of a standard troponin assay?
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In patients discharged from a general ICU, is discharge “out-of-hours” compared to discharge “in-hours” associated with subsequent in-hospital mortality?
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In children with septic shock, does a restricted fluid bolus volume, compared with a standard fluid bolus volume, improve outcomes?
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In adult patients with non-traumatic out-of-hospital cardiac arrest, does a supraglottic airway device compared with tracheal intubation as the initial advanced airway management strategy, improve functional neurological outcome?
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In patients with acute myocardial infarction complicated by cardiogenic shock and evidence of multi-vessel disease on early diagnostic angiography, does immediate multi-vessel percutaneous coronary intervention (PCI) compared to culprit lesion only PCI (with staged revascularisation) improve outcome?
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In critically ill patients on noradrenaline for haemodynamic support, who required hemofiltration for AKI, does the use of a high cutoff hemofilter compared with a standard hemofilter impact the median hours of noradrenaline-free time at day 7?
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For surrogate decision makers of critically ill patients, does a multi-component family support intervention impact on the surrogates’ hospital anxiety and depression scale (HADS) at 6 months?
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Does a neonatal intensive care team who is affected by rudeness compared to no rudeness impair team members’ diagnostic and procedural performance?
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In severely injured patients at risk for haemorrhagic shock, does prehospital plasma resuscitation, compared with standard-care resuscitation (not including plasma administration), reduce 30-day mortality?
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In adult patients with out-of-hospital cardiac arrest (OOHCA), does the administration of epinephrine compared to placebo improve survival?
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