DETO2X-AMI
In patients with suspected myocardial infarction with no baseline hypoxia, does oxygen therapy or room air improve all-cause mortality at 1 year?
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60/60 sign for Acute PE
In patients with suspected acute pulmonary embolism, do echo features of disturbed right ventricular ejection allow accurate diagnosis?
Continue reading »Seymour
In patients with severe sepsis or septic shock, does a faster time to completion of a 3 hour bundle of care, compared with a slower time, affect in hospital mortality?
Continue reading »POISE 1
In patients undergoing non-cardiac surgery, do beta-blockers compared to placebo reduce the composite of death, MI or non-fatal cardiac arrest?
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In patients with in-hospital cardiac arrest, does Shenfu (a traditional Chinese
medicine), improve 28 day mortality?
EPICC
Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial Wright. 2017. Thorax 2017: 0:1–9. doi:10.1136/thoraxjnl-2016-209858 Clinical Question Does an increased intensity of ICU based physical rehabilitation therapy improve improve long-term physical quality of life compared with a standard intensity of physical rehabilitation? Background Physical and psychological recovery after a period of critical […]
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In adults with out of hospital cardiac arrest (OOHCA) due to a presumed cardiac cause, who are post ‘return of spontaneous circulation’ (ROSC), does cooling to 33°C for 48 hours, compared with 24 hours, improve improved neurological outcomes at 6 months?
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In critically ill patients, with mild renal failure, does furosemide infusion compared to placebo worsen kidney function?
Continue reading »P-Value
P-values – interpreting the evidence series
Continue reading »Demoule
In intubated patients recovering from acute respiratory failure, does neurally adjusted ventilator assist mode (NAVA) compared to pressure support mode (PSV) lead to fewer patients returning to assist-control ventilation?
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