Seymour
In patients with severe sepsis or septic shock, does a faster time to completion of a 3 hour bundle of care, compared with a slower time, affect in hospital mortality?
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POISE 1
In patients undergoing non-cardiac surgery, do beta-blockers compared to placebo reduce the composite of death, MI or non-fatal cardiac arrest?
Continue reading »SHENFU
In patients with in-hospital cardiac arrest, does Shenfu (a traditional Chinese
medicine), improve 28 day mortality?
EPICC
Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial Wright. 2017. Thorax 2017: 0:1–9. doi:10.1136/thoraxjnl-2016-209858 Clinical Question Does an increased intensity of ICU based physical rehabilitation therapy improve improve long-term physical quality of life compared with a standard intensity of physical rehabilitation? Background Physical and psychological recovery after a period of critical […]
Continue reading »TTM 48
In adults with out of hospital cardiac arrest (OOHCA) due to a presumed cardiac cause, who are post ‘return of spontaneous circulation’ (ROSC), does cooling to 33°C for 48 hours, compared with 24 hours, improve improved neurological outcomes at 6 months?
Continue reading »SPARK
In critically ill patients, with mild renal failure, does furosemide infusion compared to placebo worsen kidney function?
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P-values – interpreting the evidence series
Continue reading »Demoule
In intubated patients recovering from acute respiratory failure, does neurally adjusted ventilator assist mode (NAVA) compared to pressure support mode (PSV) lead to fewer patients returning to assist-control ventilation?
Continue reading »Corl
In fluid responsive spontaneously breathing critically unwell patients undergoing resuscitation, does the collapsibility of the inferior vena cava (cIVC), as determined by point of care ultrasound (POCUS), when compared to administering a fluid bolus predict a >10% increase in cardiac output?
Continue reading »Hernandez 2
In critically ill patients who are at high risk for re-intubation, is high flow nasal oxygen non-inferior to non-invasive ventilation in reducing re-intubation and post-extubation respiratory failure?
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