Year: 2021

RECOVERY REGEN-COV

30 September 2021 David Slessor Intensive Care Medicine, Summaries Leave a comment

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial @PeterHorby. medRxiv pre-print 2021 doi: https://doi.org/10.1101/2021.06.15.21258542 Clinical Question In hospitalised patients with COVID-19, does the addition of monoclonal antibodies REGEN-COV (carsirivimab & imdevimab) to standard care, compared with standard care alone, improve 28 day mortality? Background Monoclonal antibodies have been shown to be […]

The REST Trial

13 September 2021 Aidan Burrell Intensive Care Medicine One comment

In mechanically ventilated patients with acute hypoxaemic respiratory failure, does lowering tidal volume using extracorporeal carbon dioxide removal, compared with conventional low tidal volume ventilation, improve day 90 all-cause mortality?

COVID STEROID 2

9 September 2021 David Slessor Intensive Care Medicine, Summaries Leave a comment

In patients with severe COVID, does 12mg dexamethasone vs 6mg dexamethasone increase the number of days alive without life support at 28 days?

COV-BARRIER

9 September 2021 Celia Bradford Intensive Care Medicine Leave a comment

In hospitalised adult patient with COVID-19, does baricitinib compared with placebo decrease a composite outcome of progression of illness and mortality?

TOMAHAWK

5 September 2021 George Walker Intensive Care Medicine Leave a comment

Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation Desch S et al. NEJM 2021. DOI: 10.1056/NEJMoa2101909 Clinical Question In adults > 30 years old suffering out-of-hospital cardiac arrest (OOHCA) without ST elevation on their ECG does routine immediate coronary angiography compared to a delayed or selective approach to coronary angiography improve 30-day all-cause mortality? Background The DISCO pilot study showed […]

Critical Care Evidence Updates – August 2021

4 September 2021 Steve Mathieu Blog, Evidence-based Medicine Leave a comment

What’s new in the Critical Care literature – monthly updates

RECOVERY-RS

22 August 2021 Celia Bradford Intensive Care Medicine 5 comments

In hospitalised patients with COVID-19 requiring >40% FiO2 to achieve SaO2>94%, does the use of continuous positive airway pressure (CPAP) or high flow nasal oxygen (HFNO) compared with conventional O2 therapy (COT) reduce the incidence of tracheal intubation or death within 30 days?

BaSICS

12 August 2021 George Walker Intensive Care Medicine Leave a comment

In adult intensive care patients does the use of a balanced crystalloid compared to 0.9% saline reduce 90-day all-cause mortality?

In adult intensive care patients needing administration of resuscitation fluids, does the slow infusion compared to a fast infusion of a fluid boluses reduce 90-day all-cause mortality?

Critical Care Evidence Updates – July 2021

2 August 2021 Steve Mathieu Evidence-based Medicine Leave a comment

What’s new in the Critical Care literature – monthly updates

McCardle

30 July 2021 David Slessor Intensive Care Medicine, Summaries Leave a comment

Treatment of Multisystem Inflammatory Syndrome in Children McArdle. NEJM 2021; 385: 35-45.DOI: 10.1056/NEJMoa2102968 Clinical Question In children with multisystem inflammatory syndrome, what affect do different treatments have on the composite of inotropic support or mechanical ventilation by day 2 or death, and disease severity by day 2? Background Multisystem inflammatory syndrome in children (MIS-C) is a new, rare but serious […]

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