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In adult patients with sepsis, severe sepsis or septic shock, is a single dose of etomidate for induction of anaesthesia, compared with any other induction, associated with a difference in mortality?
Continue reading »A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Peri-operative Medicine
In adult patients with sepsis, severe sepsis or septic shock, is a single dose of etomidate for induction of anaesthesia, compared with any other induction, associated with a difference in mortality?
Continue reading »In adults undergoing cardiac surgery, does a restrictive transfusion strategy (Hb > 75 g/l) compared to a liberal transfusion strategy (Hb > 90 g/l) lead to fewer infections and ischaemic events within 3 months?
Continue reading »In trauma patients with or at risk of significant haemorrhage, does the early administration of a short course of tranexamic acid (TXA) affect the mortality, incidence of occlusive events and the amount of blood transfused?
Continue reading »Does the application of cricoid pressure during induction of anaesthesia control the regurgitation and pulmonary aspiration of gastric or oesophageal contents?
Continue reading »In obese patients with simulated difficult laryngoscopy, does the use of nasal oxygen prolong the duration that oxygen saturations remain ≥95%?
Continue reading »In critically ill adults, does a single induction dose of etomidate compared to ketamine affect organ failure scores during the subsequent first 3 days?
Continue reading »In patients undergoing rapid sequence induction, does the use of suxamethonium or rocuronium (at a standard or higher dose), produce better intubating conditions?
Continue reading »Does chlorhexidine-impregnated dressing compared to conventional site care prevent catheter-related blood stream infections and catheter colonisation?
Continue reading »Pulmonary Artery Catheters in patient Management PAC-MAN study group, Lancet 2005;366;472-477 Clinical Question In critically ill patients, does the use of a pulmonary artery catheter (PAC) reduce mortality? Design Randomised controlled trial Non-blinded Stratified by age and presumptive clinical syndrome Intention to treat analysis Power calculation: 1281 patients would allow detection of a 10% change in absolute hospital mortality, with […]
Continue reading »In high-risk patients undergoing gastrointestinal surgery, does a cardiac output-guided haemodynamic therapy algorithm compared to clinician-guided standard therapy reduce death and major morbidity within 30 days?
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