In critically ill patients with severe metabolic acidaemia (pH ≤7⋅20), does the infusion of sodium bicarbonate, compared with no infusion, to reach and maintain a targeted pH of 7⋅30 decrease the primary composite outcome of mortality by day 28 or the presence of at least one organ failure at day 7?Continue reading »
In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?Continue reading »
In patients with septic shock, do corticosteroids compared to placebo reduce mortality?
This is an editorial blog post in anticipation of the ADRENAL trial results to be presented at #CCR18.
Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial Wright. 2017. Thorax 2017: 0:1–9. doi:10.1136/thoraxjnl-2016-209858 Clinical Question Does an increased intensity of ICU based physical rehabilitation therapy improve improve long-term physical quality of life compared with a standard intensity of physical rehabilitation? Background Physical and psychological recovery after a period of critical […]Continue reading »
P-values – interpreting the evidence seriesContinue reading »
Among relatives who died in the Intensive Care Unit (ICU), does a condolence letter from a clinician, compared to no condolence letter, effect grief symptoms?Continue reading »
What is the discriminative accuracy of physicians and nurses in predicting 6-month mortality and functional outcomes of critically ill patients?Continue reading »
Rather than reinvent the wheel, we are delighted to include a link to the RCEM Critical Appraisal Dictionary. The RCEM learning site provides excellent open access educational resources, including critical care appraisal modulesContinue reading »
In statistical hypothesis testing, a type I error is the incorrect rejection of a true null hypothesis (a “false positive”), while a type II error is incorrectly retaining a false null hypothesis (a “false negative”). The more you try and avoid a Type I error (false positive), the more likely a Type II error (false negative) may happen. Researchers have found that an alpha level of 5% is a good balance between these two issuesContinue reading »
Does the early administration of tranexamic acid (TXA), compared with placebo, reduce death from bleeding in women with post-partum haemorrhage (PPH)?Continue reading »